Semax and Selank

Semax

Type: Peptide / Nootropic / Neuroprotective
Structure: Synthetic heptapeptide (sequence: Met-Glu-His-Phe-Pro-Gly-Pro)
Primary Uses: Cognitive enhancement, neuroprotection, mood regulation

Mechanism of Action:

Semax is derived from adrenocorticotropic hormone (ACTH) fragments, but it does not have hormonal activity like ACTH.
It primarily influences the brain by modulating brain-derived neurotrophic factor (BDNF), which supports neuron growth, survival, and plasticity.
It also affects monoamine neurotransmitters (dopamine, serotonin, norepinephrine), helping improve focus, learning, and mood regulation.
Some studies suggest it may reduce oxidative stress and improve cerebral blood flow.

Effects and Benefits:

Enhanced memory, learning capacity, and attention span.
Improved mental clarity and cognitive resilience under stress.
Mild neuroprotective effects against ischemia and neurodegenerative processes.
Potential mood stabilization and anti-anxiety effects.

Administration:

Typically administered nasally for quick absorption; subcutaneous injection is also used in research settings.
Dosing varies based on intended effect, often in microgram (µg) ranges per day.

Safety:

Generally considered safe with minimal side effects when used at recommended doses.
Side effects are rare but may include mild nasal irritation or transient headaches.

Selank

Type: Peptide / Nootropic / Anxiolytic
Structure: Synthetic heptapeptide (sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro)
Primary Uses: Anxiety reduction, cognitive support, immune modulation.

Mechanism of Action:

Selank is modeled after endogenous tetrapeptides with regulatory functions in the nervous system.
It modulates GABAergic systems, promoting calm and reducing anxiety without sedation.
It also affects serotonin and dopamine systems, contributing to mood stabilization.
Evidence suggests it can increase BDNF levels and support cognitive function.
It has mild immunomodulatory properties, potentially supporting antiviral responses.

Effects and Benefits:

Reduces anxiety and stress without causing drowsiness.
Enhances memory, attention, and learning.
Supports mental resilience under stressful conditions.
May have protective effects on neurons and improve recovery after cognitive strain.

Administration:

Most commonly nasally, allowing direct access to the central nervous system.
Typical doses are also in the microgram range, with dosing frequency depending on the desired effect.

Safety:

Well-tolerated in research studies; side effects are minimal.
May cause slight nasal irritation in some users.

Summary:

Both Semax and Selank are synthetic peptides with cognitive and neuroprotective properties, primarily administered nasally.
Semax focuses more on cognition, memory, and neuroprotection, while Selank is better known for anxiolytic effects and stress resilience.
Many users combine them for synergistic effects, but careful dosing and research-backed protocols are recommended.

Semax/Selank Dosing

Common Methods: Nasal spray (most popular), subcutaneous injection (less common)

Typical Nasal Dose (for cognitive enhancement):

Low dose: 200–600 mcg per day, divided into 2–3 doses.